Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. The present study determined the Omd expression levels and investigated the effects of over‑ and under‑expression of osteoadherin in osteoblastic cells.

2019-10-18

The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone Wendel, “Osteoadherin (OSAD) is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization”. Accepted manuscript, Calcified Tissue International. DOI: 10.1007/s00223-008-9138-1 Regulation and function of mineralized tissue extra-cellular matrix proteins : Studies of ADAMTS-1 and osteoadherin. Author: Rehn, Anders. Date: 2008-06-04. A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA.

Osteoadherin

Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol. 141, 839–847). Osteoadherin (OSAD) is a bone proteoglycan containing keratan sulfate that belongs to the small leucine-rich proteoglycan (SLRP) family. Osteoadherin promotes Integrin αvβ3-mediated cell binding. The central region of Osteoadherin consists of eleven B-type, leucine-rich repeats ranging in length from 20 to 30 residues.

2019-10-18 · Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown.

Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). The primary structure of bovine osteoadherin has now been determined by nucleo … 2019-10-18 1998-07-03 Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues.

Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation. In order to further assess this role, we studied the influence of this factor in human dental pulp cells on the expression of osteoadherin (OSAD), a newly described proteoglycan found in bone and dentin and suspected to play a role in mineralization events.

The central region of Osteoadherin consists of eleven B-type, leucine-rich repeats ranging in length from 20 to 30 residues. Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet Osteoadherin is a recently described bone proteogly-can containing keratan sulfate.

The primary structure of bovine osteoadherin has now been determined by nucleotide sequencing of a cDNA clone 1997-05-01 Osteoadherin, a cell-binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix. [Y Sommarin, M Wendel, Z Shen, U Hellman, D Heinegârd] PMID 9642227 . Abstract Osteoadherin is a recently described bone … A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA. It was purified to homogeneity using a combination of ion-exchange chromatography, hydroxyapatite chromatography, and gel filtration. The Mr of the proteoglycan was 85,000 as determined by OSTEOADHERIN. From THE INSTITUTE OF ODONTOLOGY, CENTER FOR ORAL BIOLOGY Karolinska Institutet, Stockholm, Sweden REGULATION AND FUNCTION OF MINERALIZED TISSUE EXTRA-CELLULAR MATRIX PROTEINS: STUDIES OF ADAMTS-1 AND OSTEOADHERIN Anders Rehn Stockholm 2008 . 2008 Gårdsvägen 4, 169 70 Solna Osteoadherin also interacts with calcium phosphate mineral , suggesting that osteoadherin contributes to biomineralization and the control of mineral crystal nucleation, growth, and maturation.
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This modification combined with a number of aspartic and glutamic acid residues results in a highly negatively charged domain of less than 30 amino acids.

Human Osteoadherin/Osteomodulin ELISA Kit from Invitrogen (96 Tests). Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3).
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2012-02-15

The central region of Osteoadherin consists of eleven B-type, leucine-rich repeats ranging in length from 20 to 30 residues.

See more Osteoadherin/OSAD/OMD products: Catalog# EK2017: Storage & Handling: Store at 4˚C for 6 months, at -20˚C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.) Description: Sandwich High Sensitivity ELISA kit for Quantitative Detection of human Osteoadherin. 96wells/kit, with removable strips. Cite This Product

The entire Osteoadherin HDR Plasmid (h) is recommended for co-transfection with Osteoadherin CRISPR/Cas9 KO Plasmid (h) Osteoadherin HDR Plasmid (h) consists of a pool of 2-3 plasmids, each containing a homology-directed DNA repair (HDR) template corresponding to the cut sites generated by the Osteoadherin CRISPR/Cas9 KO Plasmid (h) Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

Among its related pathways are Diseases of glycosylation and HIV Life Cycle .